(Note I): antiinflammatory and analgesic activity. Galati, E.M., Monforte, M.T., Kirjavainen, S., Forestieri, A.M., Trovato, A., Tripodo, M.M.: Biological effects of hesperidin, a citrus flavonoid. Hargreaves, J.C., Adl, M.S., Warman, P.R.: A review of the use of composted municipal solid waste in agriculture. Putnik, P., Kovacevic, D.B., Jambrak, A.R., Barba, F.J., Cravotto, G., Binello, A., Lorenzo, J.M., Shpigelman, A.: Innovative “green” and novel strategies for the extraction of bioactive added value compounds from citruswastes-a review. ![]() Zema, D.A., Calabrò, P.S., Folino, A., Tamburino, V., Zappia, G., Zimbone, S.M.: Valorization of citrus processing waste: a review. Sharma, K., Mahato, N., Lee, Y.R.: Extraction, characterization and biological activity of citrus flavonoids. Sharma, K., Mahato, N., Cho, M.H.: Converting citrus wastes into value-added products: economic and environmently friendly approaches. Satari, B., Karimi, K.: Citrus processing wastes: environmental impacts, recent advances, and future perspectives in total valorization. US Department of Agriculture, Citrus: World Markets and Trade, Report July 2019. This paper describes high-yield process for extraction of hesperidin from orange peels waste, and their use as feedstock in the production of diosmetin. To add high-value to the flavanone obtained, it was subject to chemical transformation (oxidation and hydrolysis, 83% and 88% yield, respectively) into the flavone diosmetin (73% yield for 2 steps), an expensive and naturally-occurring flavonoid in low yields which exhibits a wide range of pharmacological properties. Application of described method led to 2.8% yield (w/w dry albedo) of hesperidin extracted in 89.4% purity determined by HPLC analysis. ![]() Changing to hot extraction with methanol of fresh orange albedo led to higher yields of extraction in half the time required due to the direct method, avoiding air-dried albedo step. This method involves extraction with methanol and crystallization in water with addition of dichloromethane, requiring shorter times and reducing of volume of solvent employed. The proposed process, which add high-value to this kind of residue from orange juice processing industry, was based on a successful modification applied to extraction of naringin from grapefruit. An alternative and high-yield method to obtain hesperidin, a bitter flavored flavanone glucoside, from orange ( Citrus sinensis L.
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